For instance, in experimental autoimmune encephalomyelitis (EAE), the murine model for MS (63, 66, 86), injection of the autoantigen, myelin oligodendrocyte glycoprotein (MOG) or proteolipid protein (PLP) fused to anti-DEC205-specific antibodies led to elicitation of IL-10-producing CD4+CD25+Foxp3+ Tregs, the deletion of antigen-specific CD4+ and CD8+ T cells, reduced Th17 cell activity and significantly ameliorated disease symptoms and substantially delayed the disease onset (63, 64, 67) (Figure 2). Here, CD4 is linked to experimental autoimmune encephalomyelitis.