• Transgenic mouse model expressing HLA-A2 to study antigen-specific T cell responses to HBV• Generated by co-transplantation of CD34+ HSCs and hepatic progenitors from same donor• Murine Jo2 induced mouse liver damage• Mice displayed long term viral persistence• Mice developed HBV-induced liver fibrosis, infiltration of T lymphocytes and high accumulation of macrophages. This evidence concerns the gene CD34 and Hepatic fibrosis.