PLAU and graft versus host disease: • uPA expression on NOG mouse strain has longer lifespan compared to SCID background• Irradiation was replaced with treosulfan for HSC engraftment• Generated with HLA-mismatched HSCs and mature human hepatocytes from different donors• uPA-NOG mice displayed hemato-lymphoid reconstitution and expansion of human hepatocytes• No signs of GVHD