Gene expression signatures from mice which distinguish B1 and B2 B-cells have been mapped to human orthologs; application of these signatures to human pediatric ALL transcriptomic datasets separates B1 B-cell-like ALL subtypes including ETV6-RUNX1 ALL, from B2 B-cell-like subtypes such as BCR-ABL1, hyperdiploid, and KMT2A ALL subtypes (90). This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.