This is associated with a decrease of T effector functions such as cytotoxicity and IFNγ and an increase in surface expression of many exhaustion markers including PD1, TIGIT, LAG3 and changes in transcription factors such as Eomes and TCF1 (6–8).Interestingly, anti TIGIT antibodies reactivate exhausted T cells and reduce tumor load in a mouse model of MM (8). Here, IFNG is linked to neoplasm.