Although reduced in some MM patients, CD8+ T central memory (Tcm) (CD45RA−,CD45RO+,CCR7+), T effector memory (Tem) (CD45RA+,CD45RO+,CCR7−) as well as T resident memory (Trm) (CD45RA–,CD45RO+,CD103+,CD69+) are found in the bone marrow (17, 19, 25). This evidence concerns the gene CCR7 and Miyoshi myopathy.