In CCR6 deficient ApoE−/− mice atherosclerosis levels were significantly reduced compared to littermate controls (ApoE−/−CCR6+/+) after WD feeding which can be attributed to reduction in BM derived Ly6Chi inflammatory monocyte subtype in circulation and thereby reduction in macrophage numbers in atherosclerotic lesions (20). This evidence concerns the gene CCR6 and atherosclerosis.