A similar finding was reported in CCR6 deficient LdlR−/− mice where atherosclerosis levels were significantly reduced in aorta and aortic sinus via reduction in the numbers of Gr-1hi and Gr-1low monocytes in circulation followed by reduction in accumulation of macrophage numbers in the lesions when compared to LdlR−/−CCR6+/+ control mice. This evidence concerns the gene LDLR and atherosclerosis.