In a previous case series of 14 patients from different parts of the world, several disease-causing variants were identified (Supplementary Figure 2) throughout the ARPC1B gene, and the patients demonstrated a variety of disease spectrum and severity, including recurrent bacterial and viral infections, eczema, food allergies, asthma, and thrombocytopenia (4). The gene discussed is ARPC1B; the disease is asthma.