Considering that ATP-induced NLRP3 inflammasome activation and IL-1β release play critical roles in sepsis of bacterial infection (37) and that TAS suppressed NLRP3 inflammasome activation by ATP or nigericin, we lastly investigated whether TAS was able to suppress IL-1β release in vivo and protected mice from acute bacterial infection. The gene discussed is NLRP3; the disease is bacterial infectious disease.