Adam33 is regulated in an IFNγ dependent manner in airway smooth muscle cells of asthma patients (58), Calhm6 (also known as Fam26f or Inam) both regulates IFNγ in NK cells (60) and is itself upregulated by IFNγ in lymphocytes (61), Il18bp is regulated by IFNγ (70) and it inhibits the levels of circulating IL-18 with a consequential IFNγ reduction (69). This evidence concerns the gene CALHM6 and asthma.