Thus, we investigated whether IL-12 and IL-18 signaling were required for the observed granulocytic shift after addition of CDG to Alt. Surprisingly, we found that the levels of airway eosinophilia and neutrophilia, and the number of ILC2s and ILC1s, remained constant in mice lacking IL-12 (Figures 3H,I,L, Supplementary Figures 4H,I,M) and IL-18R (Figures 3J,K,M, Supplementary Figures 4J–L). This evidence concerns the gene IL18 and Increased total eosinophil count.