CD8A and type 1 diabetes mellitus: In particular, a reduced frequency of CXCR3+T-bet+IFN-γ+ TEMRA cells within the CD8+ T cell lineage in the peripheral blood of newly diagnosed patients with T1D as compared to healthy controls was identified, in agreement with the observation of their infiltration into the insulin-positive islets wherein they constitute the most prevalent cell type responsible for pancreatic beta cell death (37).