IFNG and rheumatoid arthritis: The meta-analysis conducted by Aghaei on 11 case-controlled studies involving various populations of Europe, Asia, and American nations (97) revealed a reduction in the risk of RA considerably correlated with 2DL3 due to its inhibitory role on the secretion of cytokines, such as IFN-γ causing the diminishment of T lymphocyte autoreactivity (98, 99).