The phenotypic analysis comparing immune subpopulations in human LNs and blood from patients with new-onset T1D revealed a high number of CD8+ naïve, FOXP3+ Treg, class-switched B cells, CD56bright NK cells, plasmacytoid DCs, and CD4+ T cells in LNs (30). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.