Elemam et al. (86) found differentially expressed genes in NK cells of patients with RA, with the overexpression of IL-1β, CXCL16, BTK, ITGB7, PECAM-1, CD56, and TLR10 and the downregulation of the p65 subunit of NF-κB RELA, IBTK, CCL2, and CCR4 genes with respect to controls. This evidence concerns the gene RELA and rheumatoid arthritis.