The study evaluated 508 patients affected with RA and revealed that, if rituximab, abatacept, and tocilizumab exerted no effect on lymphocyte subdifferentiation, TNF inhibitors and age instead meaningfully influenced the numbers of NK cells, as well as of T cells, T-helper cells, T-NK cells, and γδT cells. The gene discussed is TNF; the disease is rheumatoid arthritis.