In agreement with previous data on the identification of autoantibodies to KIR in different systemic autoimmune conditions (81), the investigation on a possible association between eight different anti-KIR antibodies and pSS, conducted on 119 patients with pSS revealed that autoantibodies to at least one KIR were present in 13 patients (10.9%) (Figure 2E). This evidence concerns the gene KIR3DL1 and Autoimmunity.