From a clinical point of view, IL-6 levels seem to correlate with respiratory failure (PaO2 and SpO2), which is in line with recent studies, showing that SARS-CoV-2 activates innate and adaptive immune responses, resulting in the release of IL-6 and other cytokines, increased vascular permeability, and respiratory failure (38). The gene discussed is IL6; the disease is respiratory failure.