Moreover, the findings of the pan-cancer analysis suggested that increased levels of TBK1 expression were associated with worse OS in ESCA, KIRC, LUAD, Pheochromocytoma and Paraganglioma (PCPG), and THYM; however, they were linked to better OS in BLCA, sarcoma (SARC), and thyroid carcinoma (THCA) (Supplementary Figure 2). This evidence concerns the gene TBK1 and cancer.