In the HCC data set from TCGA, the univariate analysis indicated that vascular invasion (HR = 1.982, P = 0.029), advanced stage (HR = 2.066, P = 0.022), and high TBK1 expression (HR = 2.784, P = 0.002) significantly contribute to the poor OS. The gene discussed is TBK1; the disease is hepatocellular carcinoma.