Similarly, a recent study in a transgenic PD mouse model overexpressing human A53T mutated α-synuclein showed that blockage of the deep cervical lymph node reduces glymphatic transport of an intraventricular tracer and promotes the accumulation of α-synuclein and its aggregation in SN, thus leading to the progression of α-synuclein pathology (61). This evidence concerns the gene SNCA and Parkinson disease.