IGHE and eosinophilic esophagitis: The involvement of an adaptive Th2-type response to food antigens in EoE is well demonstrated (5, 6); several cytokines and chemokines promote food-specific responses (7, 8), during which local production of IgE (9), but also IgG4 in lamina propria of oesophageal mucosa (10) may play an important role.