(19) performed a multivariate analysis of 32 biomarkers (including SAA and CRP), out of 131 initially considered, which were subjected to three inclusion criteria: discrimination between RA patients and healthy controls, ability to identify anti-cyclic citrullinated peptide antibody (anti-CCP) negative RA patients and specificity for RA. The gene discussed is SAA1; the disease is rheumatoid arthritis.