In an H22 liver cancer murine model, administration of curdlan sulfate-matured tumor cell lysate-pulsed DCs was associated with an increase in CD80, MHC-1 and MHC-II expression, CD8+T cell infiltration, upregulated TNF-α and INF-γ transcription, and downregulation of TGF-β transcription in tumor tissues, and improved survival (263). The gene discussed is CD8A; the disease is neoplasm.