PD-1/PD-L1 inhibitors such as nivolumab, pembrolizumab and atezolizumab are now approved for the first and second line treatment of metastatic NSCLC (without actionable driver mutations) and SCLC, and as a maintenance treatment after chemoradiotherapy in inoperable stage III NSCLC (durvalumab). This evidence concerns the gene CD274 and non-small cell lung carcinoma.