TLR7 does not seem to be the absolute PRR for EV71 in the spinal cord because both WT and TLR7 KO mice are able to induce most antiviral molecules and proinflammatory cytokines with similar levels at early stage of infection (day 3 post-infection), though the levels of some anti-viral molecules are lower in TLR7KO mice compared with WT mice (Figure 3). Here, TLR7 is linked to infection.