The levels of genes associated with anti-viral effects were significantly reduced (IRF7, IFIT1, OAS1a, IL-12a), while some anti-viral genes (Mx1, ISG15, OAS1b) were somewhat reduced without reaching statistical difference in the spinal cord of TLR7KO mice compared with WT mice at day 3 post-infection (Figure 3). Here, ISG15 is linked to infection.