In addition, group 4 CVID patients also showed significantly increased blood counts vs HD of CD21- CD24- (1.15 vs 0.66 cells/μl, p=0.016) and CD21- CD24++ (4.1 vs 1.18 cells/μl, p=0.003) MBC cells, compared to with the other CVID (groups 1–3) cases (Table 1). Here, CR2 is linked to common variable immunodeficiency.