Accordingly the diagnosis of allergy has been based on three elements, one is the case history trying to relate the occurrence of allergic symptoms in a patient to exposure to certain allergen sources; the second element is trying to induce allergic reactions in the patient by exposing the person to the allergen source and recording of subsequent allergic symptoms; and the third by confirming IgE sensitization by demonstrating the presence of IgE antibodies specific for the allergen source in the blood or tissue fluids of the patient (10). This evidence concerns the gene IGHE and allergic disease.