IGHE and allergic disease: This finding suggests that for allergy similar as for other diseases such as cancer, cardiovascular diseases, and metabolic disease, early screening in the form of a preventive medical examination by determination of IgE sensitization profiles early in life might allow initiating preventive measures (e.g., allergen avoidance, early allergen-specific immunotherapy) (53–55) to prevent the development of allergic symptoms (i.e., secondary prevention) later in life.