In adult glioblastomas, CAR-T have targeted specific antigens such as human epidermal growth factor receptor 2 (HER2) (34), epidermal growth factor receptor (EGFR) vIII (35, 36), interleukin (IL)-13Rα2 (37), and ephrin type-A receptor 2 (EphA2) (38), and preliminary results are encouraging. This evidence concerns the gene EPHA2 and glioblastoma.