Previous studies have found that ferroptosis inhibitor Ferrostatin-1 alleviated atherosclerosis lesion and inhibited the iron accumulation in HFD-fed ApoE-/- mice (46), protected against early brain injury and decreased the iron content in subarachnoid hemorrhage rats (47), and inhibited death of microglia and alleviated iron overloading induced by nitrogen-doped graphene quantum dots (48). This evidence concerns the gene APOE and atherosclerosis.