Either way, in order to diagnose PCOS in women, one must look at the biochemical androgen profile, which includes free and total testosterone, SHBG, DHEAS, 17-hydroxy-progesterone and the free androgen index (FAI), estimated as the total testosterone level divided by SHBG and multiplied by 100 (51). This evidence concerns the gene SHBG and polycystic ovary syndrome.