Low-grade systemic inflammation associated with PCOS is indicated by the high levels of inflammatory markers such as interleukin-18 (IL-18), C-reactive protein (CRP), white blood count, and monocyte chemoattractant protein-1 (MCP-1), along with increased oxidative stress and endothelial dysfunction (84). The gene discussed is CCL2; the disease is polycystic ovary syndrome.