PLOD1 and polycystic ovary syndrome: Furthermore, PCOS is characterized by polycystic ovarian morphology that leads to ovarian dysfunction such oligo- or anovulation, where the central neuroendocrine systems perform an important role, due to excessive luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels and relative follicle-stimulating hormone (FSH) deficiency, that contribute to the ovarian hyperandrogenemia and altered folliculogenesis, characteristic features of PCOS (11–13).