The presence of IFNα/β is correlated with characteristic MHC class I (MHC-I) hyperexpression found in the islets of patients with T1D, suggesting that T1-IFNs enhance β cell recognition by autoreactive cytotoxic CD8+ T lymphocytes and insulin-producing pancreatic β cells through increasing MHC I expression (48). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.