Moreover, Wilm’s tumor 1 (WT1) can improve the β-catenin mediated damage of podocytes in DN by antagonizing EZH2, which is manifested in reducing the transformation of the stroma of DN podocytes, maintaining the structural integrity of DN podocytes, reducing apoptosis and oxidative stress of DN podocytes (Wan et al., 2017). Here, EZH2 is linked to liver dysplastic nodule.