EZH2 and liver dysplastic nodule: H3K27me3 and EZH2 are involved in inhibiting and maintaining the low-level and stable state of fibrosis and inflammation genes in mesangial cells, while H3K27me3 and EZH2 are inhibited by TGF-β, which increases the expression of genes that mediate glomerular mesangial dysfunction and DN, leading to renal dysfunction (Jia et al., 2019a).