Remarkably, it has been discovered in recent years that TFEB also participates in lipid metabolism through regulating lipid mobilization and oxidation, inhibiting lipid uptake, promoting intracellular lipid degradation and efflux, preventing lipid accumulation by coordinating autophagy-lysosomes and modifying lipid transporters and lipid mediators, thus alleviating the progression of atherosclerosis and stabilizing plaques (Chen L. et al., 2017; Figure 1). The gene discussed is TFEB; the disease is atherosclerosis.