RHOA and hypertensive disorder: We may speculate that this increased cofilin-1 expression could be a compensatory mechanism against aortic stiffening in SHRc, induced by high activity of the RhoA/Rho-kinase pathway, observed in hypertension (Moriki et al., 2004; Ying et al., 2004; Wynne et al., 2009; Walsh, 2011; Zhou et al., 2017).