It is well known that angiotensin II (Ang II) plays a central role in hypertension due to its potent contractile action, and drugs that inhibit Ang II signaling are widely used to treat hypertension (Schmidt-Ott et al., 2000; Marque et al., 2002; Varagic et al., 2010; Gonzalez et al., 2018). This evidence concerns the gene AGT and hypertensive disorder.