For KEGG pathway analysis, in post vs. baseline contrasts (Supplementary Table 2a) there was significant enrichment in hypermethylation of DMPs in top five KEGG pathways including: (1) MAPK signaling pathway, (2) axon guidance, (3) human papillomavirus infection, (4) small cell lung cancer and, (5) insulin secretion (Supplementary Tables 2b–f). This evidence concerns the gene INS and small cell lung carcinoma.