NR4A1 and obesity due to melanocortin 4 receptor deficiency: NR4A1 is also associated with glucose uptake, glycolysis and glycogenolysis (Chao et al., 2007), and its global knock-out is associated with an increased predisposition to obesity, insulin resistance and reduced muscle mass (Chao et al., 2009; Tontonoz et al., 2015).