INS and type 2 diabetes mellitus: Acute COD exercise evoked enriched hypomethylation in pathways such as insulin resistance and insulin signaling (specifically 30 min post exercise) that have been demonstrated to be hypomethylated in skeletal muscle of people with type-II diabetes following 6 months of aerobic exercise training (3 days/week) (Nitert et al., 2012), and in people with type-II diabetes that are non-responders to exercise (Stephens et al., 2018).