The majority of common AEs were EGFR-related skin, mucosal, and gastrointestinal reactions, including acne-like rash, diarrhea, paronychia, stomatitis, hand-foot skin reaction, and nausea, consistent with the common AEs reported for most of the EGFR-TKIs on the market (Yap et al., 2010; Bahleda et al., 2015; Califano et al., 2015; Yang et al., 2017; Kelly, Shepherd, Krivoshik, Jie and Horn, 2019). This evidence concerns the gene EGFR and stomatitis.