AKT1 and neoplasm: Furthermore, the western blot assay results indicate that isorhamnetin treatment substantially elevated the expression of cleaved PARP, p53, cleaved caspases 9, BAX, cleaved caspases 3, and p27, but downregulated BCL-2, N-cadherin, Slug, CDK1, p-PI3KP85α/γ/β, and p-AKT1 in dissected tumor tissues (Figures 7F,G).