In this study, GE significantly prevented metabolic endotoxemia and restored intestinal integrity by boosting the mRNA expression of two tight-junction proteins (ZO-1 and occludin) in HFD-fed mice, which indicated that the ability of GE to relieve NAFLD was attributed to the blunting of LPS leakage and repair of the intestinal barrier. The gene discussed is OCLN; the disease is metabolic dysfunction-associated steatotic liver disease.