Remarkably, the phosphorylations of IκB-α and NF-κB p65 proteins were suppressed in hepatic tissues, and the productions of TNF-α, IL-1β and IL-6 were decreased in the circulation and liver after GE treatment, indicating the beneficial anti-NAFLD effect of GE was at least partially attributed to the inhibition of systemic and local inflammation. Here, RELA is linked to metabolic dysfunction-associated steatotic liver disease.