These include patients suffering from Familial Adenomatous Polyposis-FAP (APC), Seckel Syndrome (ATR), Blooms Syndrome (BLM), Familial Breast or Ovarian Cancer Syndrome (BRCA1/BRCA2), Lynch Syndrome (MLH1/MSH2), Neurofibromatosis Type 1 (NF1), Familial Retinoblastoma (RB), and Li-Fraumeni Syndrome (TRP53). Here, MSH2 is linked to Li-Fraumeni syndrome.