Regarding the two potentially dangerous substances blamed for the green light in Alzheimer's disease, recent data show that amyloid and tau protein pathology should be triggered by some factors and then interact with each other, exerting a synergistic deleterious effect on the neural network, which is believed to initiate the progression of Alzheimer's disease (Morris et al., 2018). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.