It should be noted that we found alterations in astrocyte function in the neonatal stage, independent of chronic accumulation of Aβ oligomers, which starts after 6 months of age in 3xTg-AD mice, and of Tau, whose accumulation is evident after 15 months of age (Oddo et al., 2003b); however, these are research questions that must be further investigated. This evidence concerns the gene MAPT and Alzheimer disease.