CACNA2D2 and epilepsy: Loss of full-length α2δ-2 in four distinct mouse strains with naturally occurring mutations [ducky: Barclay et al., 2001; Brodbeck et al., 2002; entla: Brill et al., 2004; and ducky(2J): Donato et al., 2006] and targeted deletions in Cacna2d2 (Ivanov et al., 2004) induced epilepsy, dyskinesia, cerebellar atrophy, and high mortality in juvenile mice.