CACNA2D2 and epilepsy: This is insofar surprising as neurological disorders have been linked to aberrant α2δ subunit expression in humans: mutations in CACNA2D1 and CACNA2D2 with epilepsy (Chioza et al., 2009; Edvardson et al., 2013; Pippucci et al., 2013; Vergult et al., 2015; Butler et al., 2018), CACNA2D3 is a potential risk gene for autism spectrum disorders (Iossifov et al., 2012; De Rubeis et al., 2014), and all three genes with schizophrenia (Purcell et al., 2014; Moons et al., 2016; reviewed in Ablinger et al., 2020).