Due to the biophysical similarities between poly-GA aggregates and Alzheimer’s disease–associated amyloid-beta peptides, it is proposed that poly-GA DPRs may trigger TDP-43 pathology in C9ORF72 ALS/FTD in the same manner as the amyloid-beta neurodegeneration cascade in Alzheimer’s disease (Edbauer and Haass, 2016). This evidence concerns the gene TARDBP and early-onset autosomal dominant Alzheimer disease.