SOD1 and amyotrophic lateral sclerosis: Interestingly, genetic mutations in sALS patients have also been described, in C9orf72 (7% of cases), TARDBP, SOD1, FUS, VCP, p62, PFN-1, MATR3, OPTN, UBQLN2, CHCHD10, TBK1, TUBA4A, NEK1, C21orf2, and CCNF, together accounting for 15% of sporadic ALS cases (Taylor et al., 2016; Chia et al., 2018).