Mutations in many ALS-associated genes are associated with cellular redox dysregulation, particularly SOD1, C9orf72, FUS, TDP-43, CHCHD10, and ALS2. Furthermore, mutations in other ALS genes disrupt the cellular redox balance and induce oxidative stress (Carter et al., 2009). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.