Mutations in many ALS-associated genes are associated with cellular redox dysregulation, particularly SOD1, C9orf72, FUS, TDP-43, CHCHD10, and ALS2. Furthermore, mutations in other ALS genes disrupt the cellular redox balance and induce oxidative stress (Carter et al., 2009). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.