Similarly, increased levels of Lysosomal-associated membrane protein 1 (LAMP1) and NOX2 were detected in C9orf72 ALS/FTD patient iPSC-derived motor neurons, and in spinal cords of C9orf72 ALS patients (Liu Y. et al., 2018). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.