FXN and Friedreich ataxia: In an animal study of Friedreich Ataxia it was shown that long-term RGFP109 treatment (100 mg/kg over a period of 5 months with five injections per week) increased especially local H3K9ac and H4K5ac levels directly at the frataxin gene accompanied by higher frataxin gene expression levels in mouse brain, whereas global H3 and H4 acetylation patterns did not significantly increase by the drug (Sandi et al., 2011).