In line with our findings, Suelves et al. demonstrated that selective HDAC3 inhibition by RGFP966 in the HdhQ7/Q111 knock-in mouse model of HD (50 mg/kg of RGFP966 three times per week from 3 to 6.5 months) prevents corticostriatal-dependent motor learning deficits from trial four on testing animals for four times per day for 3 consecutive days (Suelves et al., 2017). This evidence concerns the gene HDAC3 and Huntington disease.