Further, Arhgap15 (Rho GTPase activating protein 15) and Gsto2 (Glutathione S-Transferase Omega 2), genes whose expression were completely rescued in a previous report by the HDAC1 and HDAC3 selective inhibitor HDACi 4b in R6/2s (Thomas et al., 2008), were also restored in our study upon RGFP109 treatment in R6/1s, supporting a similar mode of action of these selective HDAC inhibitors across different models of HD. This evidence concerns the gene HDAC1 and Huntington disease.