Collectively, RGFP109 treatment, at least to a certain extent, repairs the transcriptional effects of mutant Huntingtin gene expression, causing a significant change in the expression of 43 genes, in the striatum of R6/1 mice and induced collective changes in the expression of a number of gene sets and pathways, some of which were associated to biological functions and processes that are relevant for neuronal physiology and HD pathogenesis. This evidence concerns the gene HTT and Huntington disease.