Intraperitoneal injection of CS-6253 injection, an ABCA1 agonist peptide, increased apoE4 lipidation, decreased Aβ accumulation and tau hyperphosphorylation as well as reduced cognitive deficits in APOE4-TR mice (Boehm-Cagan et al., 2016). The gene discussed is ABCA1; the disease is Cognitive impairment.