In humans, there was however no isoform-dependent variations in levels of apoE in the CSF in young control subjects (average 34.5 years) (Baker-Nigh et al., 2016), cognitively healthy subjects (average 61 years) and AD patients (average 78 years) (Martínez-Morillo et al., 2014). This evidence concerns the gene APOE and Alzheimer disease.