Detergent-resistant aggregates isolated from the spinal cords of ALS transgenic mice contain full-length apo hSOD1 proteins that acquire toxic properties in the disease mechanism (Shaw et al., 2008), and SOD1 fibrils have been shown to induce cytokine expression in mononuclear cells, thus causing inflammation (Fiala et al., 2010), and to activate microglial cells (Roberts et al., 2013), suggesting that fibrils have toxic properties that may be related to ALS. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.