MAPT and Cognitive impairment: While our work provides evidence that tau deletion prevents cognitive impairment during aging, other studies using tauGFP knock-in/knock-out mice (Stock No: 029219 | tauGFP, Jackson Laboratory) or C57Bl6/SJL (F1) female mice (Stock No. 100012, Jackson Laboratory) injected with Adeno-associated virus (AAV) construct containing a shRNA to MAPT gene showed that tau ablation in the hippocampus causes learning and memory deficits (Biundo et al., 2018; Velazquez et al., 2018).