H19 and neoplasm: After ingestion of renal CSCs-derived EVs, the phenotype of MSCs changed significantly, including increased expression of genes related to matrix remodeling, angiogenesis, tumor growth, as well as cell migration.179 Tumorigenic MSCs in turn promoted angiogenesis and tumor growth in renal cancer.179 In addition, CSCs-like CD90+ liver cells regulated the endothelial phenotype by releasing exosomes containing lncRNA H19.