LncRNA MALAT1 and linc-ROR are expressed in multiple cancer types and are associated with cancer metastasis and EMT.166 It was found that lncRNA MALAT1 and linc-ROR, as well as the EMT marker SLUG and the stem cell transcription factor SOX2 in thyroid CSCs-derived exosomes, were significantly upregulated.165 Thyroid CSCs-derived exosomes induced EMT program of normal thyroid cells and increased their aggressiveness.165. The gene discussed is SOX2; the disease is cancer.