H19 and neoplasm: The researchers found that exosomal lncRNA H19 of CD90+ liver CSCs significantly increased the expression of VEGF, and promoted heterotypic adhesion between endothelial cells and CD90+ liver CSCs.16 In a study on ovarian cancer, Vera et al.180 revealed the cross talk between small EVs released from ovarian cancer spheroids (OCS) and MSCs to exert tumor-promoting activity.