IL6 and neoplasm: Under the stimulation of cisplatin, small EVs derived from CSCs-rich OCS induced the migration of bone marrow MSCs and promoted their secretion of IL-6, IL-8, as well as VEGF-A.180 These cytokines secreted by bone marrow MSCs in turn stimulated the angiogenic activity of HUVEC cells, and thus contributing to tumorigenic processes.180 In summary, the above results indicate that EVs released by CSCs interact with tumor microenvironmental stromal cells to promote tumor malignant phenotype (Table 3).