TLR7 and esophageal squamous cell carcinoma: Exosomal lncRNA FMR1-AS1 bound to endosomal toll-like receptor 7 (TLR7) and activated downstream TLR7/NF-κB signaling to promote c-Myc expression, thereby inducing ESCC cell proliferation, anti-apoptosis, and invasion ability154 (Fig. 3).