CGAS and viral infectious disease: These data lend support to preclinical observations that the cGAS/STING/type 1 interferon pathway, the biology of which is critical in the immune response to viral infection, is important in the radiation-induced immune response.46 47 They also indicate that further study of the relationship between radiation-induced DNA damage and the immune response is warranted, including possible synergy with DNA damage response inhibitors13 48