Furthermore, compared with the HPI− group, the NLRP3 positive cell rate in the HPI+ group were significantly higher (P < 0.01) at 0.5, 6 and 9 h after infection, the caspase-1 positive cell rate in the HPI+ group were significantly higher (P < 0.01) at 3 and 6 h after infection. The gene discussed is CASP1; the disease is infection.