In addition, kaempferol, quercetin, rutoside and other compounds regulate the fluid shear stress and atherosclerosis pathway by acting on IL-1B, JUN and BCL2 target proteins, indicating that the combined use of drugs has a synergistic effect, which is consistent with the multi-component, multi-target and multidimensional pharmacological effects of TCM in the treatment of diseases. This evidence concerns the gene JUN and atherosclerosis.