In contrast, genes pertaining to DNA helicase, ATPase, serine threonine kinase, and microtubular motor activities were upregulated against BPH but down-regulated against WBPH, and structural constituents of ribosome, calcium ion binding and electron carrier activity related genes were down-regulated against BPH but upregulated against WBPH. Here, MARK2 is linked to benign prostatic hyperplasia.