Janelidize et al. described high accuracy (AUC = 0.93, sensitivity = 0.92, specificity = 0.87) in detecting AD from non-AD neurodegenerative disorders [80] which was comparable to CSF measures of Aβ and t-tau and only slightly inferior to CSF p-tau181 and tau PET. The gene discussed is MAPT; the disease is Alzheimer disease.