Consequently, both genotype (truncating vs. non-truncating PKD1, PKD1 vs. PKD2) and total kidney volume have been integrated into scoring systems to predict the individual likelihood of reaching kidney failure (e.g., PROPKD Score) together with clinical risk factors such as gender and hypertension or urological events before the age of 35 years [50]. This evidence concerns the gene PKD2 and Hypertension.