GAD2 and Autoimmunity: For example, autoantibodies might be an epiphenomenon not related to the main pathophysiology such as cellular immunity, i.e., cytotoxic CD8 + T-cells (Langenbruch et al. 2020); GAD65 autoantibodies themselves do not represent a major part of the autoimmunity process, as intrathecal GAD65 antibody production is often unproven (for review see Graus et al. 2020).