Liu and Frostegård have shown that silencing of PCSK9 could reverse oxLDL-induced maturation of dendritic cells (DCs) and subsequent T cell activation, while inducing regulatory T cells with IL-10 production.3 However, the molecular mechanisms underlying the direct influence of PCSK9 in atherosclerosis pathogenesis and regression remain to be elucidated. Here, PCSK9 is linked to atherosclerosis.